Solution-Explain why mutations of the framework region of

1. Somatic hypermutation of antibody variable regions can occur during an immune response. It allows daughter cells to produce antibodies with a slightly different V region than the parent cell. Give one reason why this might be important for the efficacy of the antibody response. Explain why mutations of the framework region of an antibody might be more detrimental to the antibody than mutations in CDR’s

2. You learned that a B-cell only uses one allele of it’s heavy and light chains. What is this process called?

What problems may arise if during an immune response if more than one gene was used in each B-cell?

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